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In 1972, a team of internationally recognized scientists set out to conduct a study of the role of hormonal balance in the aging process. Specifically, whether it is possible to slow or reverse biological aging by stimulating the function of the hypothalamus, the master gland that closely controls hormones in the body.
In their study, researchers used female rats that were at various stages of menopause. Why menopause? Because during menopause, the correlation of aging and hormonal balance can be seen at its extreme.
Researchers revived hypothalamic sensitivity in rats by administering a mixture of succinates (prototype of Amberen). The results were astounding. Animals showed broad signs of rejuvenation, ranging from increased energy and health to younger-looking fur. In early menopausal rats, menopause was completely reversed. Post-menopausal rats grew healthy bone mass at a faster rate than younger rats.
The study proved that primary cause of aging and menopause lies in the brain and that it begins with the hypothalamus losing sensitivity to signals from organs and tissues. It also proved that even as ovaries stop supplying hormones and menopause sets in, the ovaries still have follicles that can produce hormones, if their communication with the hypothalamus is restored.
Following the study, leading team member, Prof. Kondrashova, made a crucial scientific discovery that succinates can mimic the effect of signaling hormones.
Later, researchers in the US affirmed her findings when they discovered special receptors in the brain that receive succinate signals.
The discoveries made in those studies led to the development of Amberen.
In the same year, Amberen was successfully tested in human clinical trials.
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Type of Study |
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Human Clinical Trials
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Protocol |
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Randomized, double blind, placebo-controlled, cross over clinical trials.
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Results |
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Excerpt from Amberen Clinical Trial Report. “Amberen-based monotherapy significantly lowered most subjectively evaluated characteristics of menopausal syndrome. Amberen monotherapy also alleviated symptoms of some neurovegetative and psycho-emotional disorders, such as hot flushes, headache, and anxiety.”
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Adverse Side-effects |
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No side-effects registered
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Peer-reviewed Publications |
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(2008) A Succinate-Based Composition Reverses Menopausal Symptoms Without Sex Hormone Therapy Advances in Gerontology. 21 (2) 298–305.
Click here to view abstract on Pubmed.gov
(2005) Succinate-Based Preparation Alleviates Manifestations
of the Climacteric Syndrome in Women
Bulletin of Experimental Biology and Medicine/Pharmacology and Toxicology. (140)3.
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Type of Study |
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Five-year Clinical Study of 32 Menopausal Women
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Protocol |
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Randomized, Placebo Controlled
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Results |
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Amberen alleviated symptoms of menopause when administered as monotherapy. In women who were undergoing electro-acupuncture treatment (EAT), adding Amberen to the regimen showed optimized results from the EAT.
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Adverse Side-effects |
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No side-effects registered
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Peer-reviewed Publications |
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Ulyanovsk State University Journal, 2007
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Type of Study |
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Animal Study
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Protocol |
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Administration of micromolar concentrations of succinic and glutamic acids to laboratory rats in various stages of menopause.
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Results |
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Succinate-based treatment restored sensitivity of the hypothalamus to negative feedback signals; Reversed menopause-related bone loss; Reversed most biochemical manifestations of menopause; Animals showed broad signs of rejuvenation.
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Adverse Side-effects |
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No adverse side-effects registered.
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Peer-reviewed Publications |
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The influence of succinic and glutamic acids on hypothalamic-hypophyseal system sensitivity to inhibitory effect of estrogens in old rat.
V.N.Anisimov, V.M. Dilman and M,N. Kondrashova.
Pharmacology & Toxicology (Russ) Moscow, 1976, v. 39, p. 540-543. |
Type of Study |
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Animal Study
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Protocol |
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Evaluation of four-week Amberen treatment on the estral cycle, bone mass and calcium content of aging mice.
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Results |
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Amberen therapy alleviated many biochemical symptoms of menopause in aging mice.
“The administration of SBC to aging mice had a favorable effect on the appearance and behavior of animals—they became more active, their lackluster eyes acquired brightness, and the pale, yellowish coat regained white color and shine, resembling the coat of young animals. The bald skin spots grew new hair.”
 
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Adverse Side-effects |
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No adverse side-effects registered.
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Peer-reviewed Publications |
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MEDLINE.RU (International Online Biomedical Journal) VOL. 8, GERONTOLOGY, ENDOCRINOLOGY SEPTEMBER 2007
A succinate-based composition ”rejuvenates” aging mice and alleviates menopausal symptoms in women without sex hormone replacement therapy” |
Type of Study |
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Animal Study
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Protocol |
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Six-week laboratory study of biochemical effects of Amberen treatment in old female rats.
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Results |
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Amberen corrects ovulation cycle in old female rats
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Adverse Side-effects |
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No adverse side-effects registered.
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Peer-reviewed Publications |
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Manuscript is being prepared for submission to a peer-reviewed publication
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