Amberen's History

In 1972, a team of internationally recognized scientists set out to conduct a study of the role of hormonal balance in the aging process. Specifically, whether it is possible to slow or reverse biological aging by stimulating the function of the hypothalamus, the master gland that closely controls hormones in the body.

In their study, researchers used female rats that were at various stages of menopause. Why menopause? Because during menopause, the correlation of aging and hormonal balance can be seen at its extreme.

Researchers revived hypothalamic sensitivity in rats by administering a mixture of succinates (prototype of Amberen). The results were astounding. Animals showed broad signs of rejuvenation, ranging from increased energy and health to younger-looking fur. In early menopausal rats, menopause was completely reversed. Post-menopausal rats grew healthy bone mass at a faster rate than younger rats.

The study proved that primary cause of aging and menopause lies in the brain and that it begins with the hypothalamus losing sensitivity to signals from organs and tissues. It also proved that even as ovaries stop supplying hormones and menopause sets in, the ovaries still have follicles that can produce hormones, if their communication with the hypothalamus is restored.

Following the study, leading team member, Prof. Kondrashova, made a crucial scientific discovery that succinates can mimic the effect of signaling hormones.

Later, researchers in the US affirmed her findings when they discovered special receptors in the brain that receive succinate signals.

The discoveries made in those studies led to the development of Amberen.

In the same year, Amberen was successfully tested in human clinical trials.

Amberen's Clinical Trials

Type of Study	Human Clinical Trials
Protocol	Randomized, double blind, placebo-controlled, cross over clinical trials.
Results	Excerpt from Amberen Clinical Trial Report. “Amberen-based monotherapy significantly lowered most subjectively evaluated characteristics of menopausal syndrome. Amberen monotherapy also alleviated symptoms of some neurovegetative and psycho-emotional disorders, such as hot flushes, headache, and anxiety.”
Adverse Side Effects	No side effects registered
Peer-reviewed Publications	(2008) A Succinate-Based Composition Reverses Menopausal Symptoms Without Sex Hormone Therapy. Advances in Gerontology, Vol. 21, No. 2, pp. 298-305. Click here to view abstract on Pubmed.gov (2007) A Succinate-Based Composition ”Rejuvenates” Aging Mice and Alleviates Menopausal Symptoms in Women Without Sex Hormone Replacement Therapy. Medline (Gerontology, Endocrinology), Vol. 8, Art. 46, pp. 497-517. Click here to read full article (2005) Succinate-Based Preparation Alleviates Manifestations of the Climacteric Syndrome in Women. Bulletin of Experimental Biology and Medicine (Pharmacology, Toxicology), Vol. 140, No. 3, pp. 312-314. Click here to view abstract

Type of Study	Five-year Clinical Study of 32 Menopausal Women
Protocol	Randomized, Placebo Controlled
Results	Amberen alleviated symptoms of menopause when administered as monotherapy. In women who were undergoing electro-acupuncture treatment (EAT), adding Amberen to the regimen showed optimized results from the EAT.
Adverse Side Effects	No side effects registered

Type of Study	Animal Study
Protocol	Evaluation of four-week Amberen treatment on the estral cycle, bone mass and calcium content of aging mice.
Results	Amberen therapy alleviated many biochemical symptoms of menopause in aging mice. “The administration of SBC to aging mice had a favorable effect on the appearance and behavior of animals—they became more active, their lackluster eyes acquired brightness, and the pale, yellowish coat regained white color and shine, resembling the coat of young animals. The bald skin spots grew new hair.”
Peer-reviewed Publications	No side-effects registered

Type of Study	Animal Study
Protocol	Six-week laboratory study of biochemical effects of Amberen treatment in old female rats.
Results	Amberen corrects ovulation cycle in old female rats.
Peer-reviewed Publications	Manuscript is being prepared for submission to a peer-reviewed publication